EFFECT OF ELEMENTAL SELENIUM AT NANO SIZE (Nano-Se) WITH LOWER TOXICITY ON THE ANTI-TUMOR EFFECT OF CISPLATIN / 营养学报
Acta Nutrimenta Sinica
;
(6)2004.
Artículo
en Chino
| WPRIM
| ID: wpr-562261
ABSTRACT
Objective:
To investigate the effect of Nano-Se with lower toxicity on the anti-tumor effect of cisplatin.Method:
For toxicity comparison, mice were orally administered Nano-Se and sodium selenite to observe death, body weight loss and liver injury. As to the protective effect of Nano-Se on the toxicity of cisplatin, mice with and without Nano-Se supplementation were injected cisplatin to observe death and body weight loss. For evaluation of whether Nano-Se influence the anti-tumor effect of cisplatin, Lewis lung carcinoma was transplanted into mice, and the survivor and tumor volume were recorded to compare the effect of Nano-Se supplementation on cisplatin.Results:
The toxicity of Nano-Se is significantly lower than sodium selenite. Nano-Se can decrease toxicity of cisplatin without compromising its anti-tumor effect.Conclusion:
Nano-Se with lower toxicity can improve the therapeutic effect of cisplatin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Acta Nutrimenta Sinica
Año:
2004
Tipo del documento:
Artículo
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