The effect of vitamin C on hemodynamics and arterial blood gas in tourniquet induced ischemia-reperfusion injury during unilateral total knee replacement in elderly patients
Anesthesia and Pain Medicine
;
: 277-281, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-56368
ABSTRACT
BACKGROUND:
Free radicals, such as reactive oxygen species which are released abruptly after deflation of an ischemic tourniquet, cause reperfusion injuries. Vitamin C produce cytoprotective effects due to reduction of free radicals. This study was designed to investigate the effect of vitamin C on hemodynamics and arterial blood gas during unilateral total knee replacement.METHODS:
In the vitamin C group (VC group N = 19), patients were administrated with vitamin Ca priming bolus of vitamin C 0.06 g/kg mixed with 100 ml saline infused for 20 min at 10 min before deflation of tourniquet, followed by vitamin C 0.02 g/kg mixed with 30 ml saline at 0.5 ml/min. In the control group (control group N = 15), patients were infused by 100 ml saline. Mean arterial blood pressure, heart rate and arterial blood gas were measured at 20 min after anesthesia induction, just before deflation, 5 min after deflation and 20 min after deflation of tourniquet.RESULTS:
Mean arterial blood pressure in the VC group was maintained higher than control group at 1 min after deflation of the tourniquet. Arterial O2 tension and saturation in the VC group were higher than control group at 5 min and 20 min after deflation of the tourniquet.CONCLUSIONS:
We concluded that the administration of vitamin C during total knee replacement could inhibit decline of mean arterial blood pressure and arterial oxygenation induced by ischemiareperfusion significantly.
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxígeno
/
Ácido Ascórbico
/
Torniquetes
/
Vitaminas
/
Daño por Reperfusión
/
Especies Reactivas de Oxígeno
/
Artroplastia de Reemplazo de Rodilla
/
Presión Arterial
/
Radicales Libres
/
Frecuencia Cardíaca
Límite:
Anciano
/
Humanos
Idioma:
Coreano
Revista:
Anesthesia and Pain Medicine
Año:
2008
Tipo del documento:
Artículo
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