Hepatitis B surface antigen terminates codon bias selection / 北京大学学报(医学版)
Article
en Zh
| WPRIM
| ID: wpr-563713
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WPRO
ABSTRACT
Objective:To investigate the existence condition of hepatitis B surface antigen(HBsAg) termina-tion codon bias.Methods: A total of 174 reference sequences of all kinds of Hepatitis B virus(HBV) genotypes were chosen from GenBank,and compared by BioEdit.Then secondary structure of RNA was constructed and analyzed together.Results:(1) There were two types of HBsAg termination codon: TAA and TGA in 174 reference sequences.TAA was in 124 cases(71.26%);and TGA in 50 cases(28.74%).(2) There was codon bias selection in HBsAg termination codon,and it could affect the secondary structure of RNA and amino acid sequence encoding protein.Conclusion: HBsAg termination codon bias exists and may be related to RNA structure and the conservatiom of protein function in the evolutionary progress.
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WPRIM
Idioma:
Zh
Revista:
Journal of Peking University(Health Sciences)
Año:
2004
Tipo del documento:
Article