Validation of a Scoring System for Predicting Malignancy in Patients Diagnosed with Atypical Ductal Hyperplasia Using an Ultrasound-Guided Core Needle Biopsy / 한국유방암학회지
Journal of Breast Cancer
; : 407-411, 2012.
Article
en En
| WPRIM
| ID: wpr-56438
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The need for surgical excision in patients with ultrasound-guided core needle biopsy (CNB)-diagnosed atypical ductal hyperplasia (ADH) remains an issue of debate. The present study sought to validate a scoring system (the U score, for underestimation) that we have previously developed for predicting malignancy in CNB-diagnosed ADH. METHODS: The study prospectively enrolled 85 female patients with CNB-diagnosed ADH who underwent subsequent surgical excision. Underestimation was defined as a surgical specimen having malignant foci. RESULTS: The overall underestimation rate was 37% (31/85). Multivariate analysis showed that a clinically palpable mass, microcalcification on imaging, size >15 mm and a patient age of > or =50 years were independently associated with underestimation. When applied to the scoring system, the validation score was significant (p<0.001; area under the curve, 0.852). No patient with a U score <3.5 had an underestimated lesion. CONCLUSION: The present study successfully validated the efficacy of our scoring system for predicting malignancy in CNB-diagnosed ADH. A U score of < or =3.5 indicates that surgical excision may not be necessary.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Biopsia con Aguja
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Neoplasias de la Mama
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Análisis Multivariante
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Estudios Prospectivos
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Errores Diagnósticos
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Biopsia con Aguja Gruesa
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Hiperplasia
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Límite:
Female
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Humans
Idioma:
En
Revista:
Journal of Breast Cancer
Año:
2012
Tipo del documento:
Article