The research progress of BAPTA-AM / 中国药理学通报

ABSTRACT

BAPTA-AM is a standard tool agent of calcium chelating.After entering into cells,BAPTA-AM is metabolized by lipase and forms BAPTA.The latter combines with calcium ion rapidly and high selectivity.The effects of BAPTA-AM can effectively protect nerve cells against hypoxic/ischemic injury and protect hepatocytes against cytotoxins attack.BAPTA-AM is a hopeful candidate for treating stroke,liver failure and other clinical critical diseases.