Protection and its mechanism of two flavone morphons from Yulangsan on hypoxia-reoxygenation induced injury in myocardial cells / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)2003.
Article
en Zh
| WPRIM
| ID: wpr-566004
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WPRO
ABSTRACT
Aim To observe the protective effects of two flavone morphons on hypoxia/reoxygenation(H/R) injury in myocardial cells and explore the mechanisms.Methods The hypoxia/reoxygenation injury model of cultured neonatal rat cardiomyocytes was developed. The cell morphology,the spontaneous beating,the survival rate,the content of LDH,NOS,T-SOD,MDA and the activity of Na+,K+-ATP,Ca2+,Mg2+-ATP enzyme were determined in the cultured neonatal rat cardiomyocytes injuried by H/R.Results Compared with the model,preconditioning by two flavone morphons enhanced the spontaneous beating and the survival rate. Meanwhile,it increased the activity of T-SOD,Na+,K+-ATP,Ca2+,Mg2+-ATP enzyme and decreased the release of LDH,NOS,MDA(P
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Zh
Revista:
Chinese Pharmacological Bulletin
Año:
2003
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Article