DJ-1 gene:a new potential target of drugs for Parkinson's disease / 中国药理学通报

ABSTRACT

Parkinson's disease (PD) is a neurodegenerative disease commonly found in middle-aged and elderly people,and its onset is attributable to both genetic and environmental factors. The gene mutation and oxidative damage of DJ-1 correlate with familial and sporadic PD,respectively. The mechanisms by which DJ-1 gene mutation and oxidative damage lead to PD include oxidative stress,mitochondrial dysfunction and proteasome dysfunction.Furthermore,DJ-1 is a biomarker of sporadic PD and it may become a new potential target of anti-PD drugs.