Evolutionary trend of the novel A/H1N1 influenza virus in 2009 and the major problems concerning prevention and control of this pandemic / 解放军医学杂志

ABSTRACT

Objective Eight functional fragments of the novel A/H1N1 influenza pandemic virus in 2009 had their own evolutionary characteristics.Among them,the hemagglutinin(HA),the major antigenic gene,was originated from swine influenza virus epidemics in North America.The HA gene,polymerase genes(PB2,PB1 and PA),nucleoprotein gene(NP) and nonstructural protein gene(NS) of the virus strain isolated in Iowa of US in 2005 shared close homology(identities more than 90%) with the corresponding sequences of the novel A/H1N1 influenza pandemic virus in 2009.The Iowa strain might be an intermediate step of the evolutionary process of this novel A/H1N1 influenza virus.The evolutionary process of the novel A/H1N1 influenza might be realized in pigs re-assorted with the neuraminidase(NA) gene from European swine H1N1 influenza virus and matrix proteins(M1 and M2) genes from European H3N2 swine influenza virus.The present paper presented possible evolutionary processes of the novel A/H1N1 influenza pandemic virus in 2009,and pointed out several relevant scientific points which should be emphasized in the prevention and control of the epidemics of the novel A/H1N1 influenza in near future.