The Effect of NK Cell Function in Peripheral Blood of Patients with Advanced Primary Liver Cancer During Interventional Treatment / 介入放射学杂志

ABSTRACT

NK cell function was tested in 60 patients randomly selected with ad- vanced primary liver cancer(PLC)during interventional treatment.The patients were di- vided into three groups and treated with different regimens.In group 1(n=20),routinally using HAI(5-Fu 1000mg,CDDP 30mg)and HAE(Lipiodel 10～20ml,EAMC 50mg)in group 2,the treatment project is same as in group 1,but after the treatment,total 8g Natrii thiosulfas was administrated intravenously within 48 hours;in group 3,one week after treatment as in group 1,the patients received a-2b IFN injected subcutaneously at a dose of 10?10~6 IU,B.i.w,for more than 2 months.The results showed that1.NK function in the patients with advanced PLC was 17.45?4.5% ,significantly lower than that in the nor- mal ones(21.39?3.58%);2.After the interventional treatment,the NK function of the patients were obviously decreased in group 1(13.58?3.14%),and in group 2(15.45?2. 69%),but increased in group 3(19.20?3.27%).The results suggested that conventional interventional treatment will affect NK cell function of patients with advanced PLC in some degree,and the effect can be reduced by injecting Natrii Thiosulfas i.v.,and administering IFN.