Influence of ?-3 PUFA on bacterial pneumonia in mice / 肠外与肠内营养
Parenteral & Enteral Nutrition
; (6)1997.
Article
en Zh
| WPRIM
| ID: wpr-566899
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To evaluate the protective effect and possible mechanism of ?-3 PUFA supplementation in the early stage of experimental acute bacterial pneumonia in mice.Methods: Mice of Pseudomonas aeruginosa(PA)-induced lung injury were randomly divided into three groups: fish oil supplementation treatment group(n = 8),soybean oil treatment group(n = 8) and normal sodium treatment group(n = 8).Evaluation criteria were inflammatory response 24 h after the injury assessed with TNF-?、IL-1?,IL-10 levels in bronchoalveolar lavage and lung injury evaluation by H-E staining.Results: Compared with the other two groups,the levels of IL-1?,IL-10 in fish oil supplementation treatment group were reduced.No difference was found in the TNF-? level and histological scoring among the groups.Conclusion: The ?-3 PUFA can decrease the elevated mediators of inflammation in bacterial pneumonia,but can't affect the pneumonia progress within 24 hours.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Parenteral & Enteral Nutrition
Año:
1997
Tipo del documento:
Article