Effect of puerarin on the expression of NF-?B65 and TNF-? in kidney of diabetic rats / 解放军医学杂志
Medical Journal of Chinese People's Liberation Army
;
(12)1981.
Artículo
en Chino
| WPRIM
| ID: wpr-567708
ABSTRACT
Objective To observe the effect of puerarin on the expression of NF-?B65 and TNF-? in kidney of diabetic rats. Methods SD rats were randomly assigned to 5 groups (10 each)normal control group (group A),diabetic group (group B),low-dose,middle-dose and high-dose treatment groups (group C,D and E). After diabetes model was reproduced,animals in group C,D and E were i.p. injected with puerarin in a dose of 40,80 and 160mg/(kg?d),respectively; animals in group A and B were treated with corresponding normal saline. Fasting blood glucose (FBG),urinary albumin excretory rate (UAER),serum creatinine (Scr) and blood urea nitrogen (BUN) were determined at the 8th weekend after treatment. The histological changes in renal cortex were observed with light microscope and electron microscope. The qualitative and semi-quantitative expressions of NF-?B65 and TNF-? in nephridial tissue were determined by immunohistochemical method. Results FBG,UAER,Scr and BUN were higher in group C,D and E than that in group A (P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
/
Investigación cualitativa
Idioma:
Chino
Revista:
Medical Journal of Chinese People's Liberation Army
Año:
1981
Tipo del documento:
Artículo
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