Effects of blood loss during operation on coagulation function in selective non-cardiovascular surgery patients / 解放军医学杂志

ABSTRACT

Objective To investigate the change in coagulation function in relation to different amounts of blood loss in selective non-cardiovascular surgery patients.Methods Twenty American Anesthesia Association (ASA) class I or Ⅱ patients,aged 23-57 yr,undergoing non-cardiovascular surgery with normal preoperative coagulation were chosen randomly.After general anesthesia,on the basis of adequate sedation and analgesia,patients were given Ringer's solution and Voluven (pre-warmed to 37℃,volume ratio of crystalloid/colloid was 12) to maintain the stability of heart rate,blood pressure and central venous pressure.Temperature and blood gas analysis were monitored to prevent potential interference induced by hypothermia and acidosis.When the ratio of blood loss/blood volume reached 10%,15%,20% and 25%,all the routine blood components analysis and coagubility parameters,and Sonoclot coagulation and platelet function parameters were observed.Results Preoperative average value of Hct was 38.1%,and when ratio of blood loss/blood volume were 10%,15%,20 % and 25%,Hct was decreased to 33.4%,31.5%,30.1% and 27.9% respectively.When the ratio reached 15% or larger,platelet count decreased significantly compared with preoperative value (P