AN EXPERIMENTAL MORPHOLOGICAL STUDY OF THE INTRAMURAL VASCULAR CHANGES AFTER LIGATING THE LEFT CORONARY ARTERY IN RATS / 解剖学报

ABSTRACT

Intramural vescular changes in the healing process after myocardial infarction were studied by the methods of histological section after ligating the left coronary artery of 119 rats. The intramural vascular patterns in the left ventricular free wall of the rat heart are similar to those of the human and the rabbit, but the patterns in the interventricular septum of the rat heart are only similar to those of the rabbit. The left ventricutar free wall contains 3,903?48 capillaries per mm~2 on the average. The capillaries in all areas run parallel with the myocardial fibres. After figuring the left coronary artery of the rat heart,the intramural vascular changes may be divided into three stages, i.e.avascularity, hypervascularity and hypovascularity, which coincide with the healing process of myocardial infarction. It is suggested that the coronary collateral circulation begins within the first two days, and increases gradually during 3 to 7 days after myocardial infarction. The evolutionary process of blood vessels in experimental myocardial infarction of rats is more rapid than that in the human and in the rabbit, but the process itself is similar to each other.