Clinical Studies on Propofol ( Diprivan ) / 대한마취과학회지

ABSTRACT

Twenty one patients undergoing elective orthopedic or gynecologic operation were randomly assigned to receive anesthesia with propofol 2.0mg-propofol infusion 6~10 mg/kg/hr-nitrousoxide 50%(propofol group) or thiopental 4~5mg/kg-isoflurane-nitrous oxide 50%(Thiopental group). The cardiovascular effects were initial decreases of systolic, diastolic, mean arterial pressure, cardiac output and stroke volume and increase in heart rates. There was no difference between broups. AFter tracheal intubation systolic, diastolic and mean arterial pressure increased in propofol group but not in isoflurane group. During maintenance tehre was no difference in hemodynamic parameters between groups. Hematologic, renal and hepatic functions revealed no difference between pre-and post-anesthesia in both groups. The cortisol levels were not changed after anesthesia in both groups. The recovery time was significantly shorter in porpofol group than in isoflurane group.