Experimental Study of Transctheter Bilaterial Internal Iliac Artery Infusion with HCPT / 介入放射学杂志
Journal of Interventional Radiology
;
(12)1994.
Artículo
en Chino
| WPRIM
| ID: wpr-569459
ABSTRACT
Purpose:
To evaluate the different concentration of HCPT in rabbit blood and bladder tissue between intraarterial and intravenous penfusion groups.To indentify the probability of using HCPT as a new type of anti-tumor agent delivered by the intra-arterial pesfusion method for the treating of bladder cancer.Materials andmethods:
Group A40 white female rabbits were divided into 2 groups(intraarterial and intravenous)and each was subdivided according to the time intervalsof bladder tissue sampling,of 5,15,30,60,120 minites after the drug delivering.Group B16 white female rabbits equally divieded into 2 groups(intraarterial and intravenous)for dynamic blood sampling by the intervals of 5,15,30,60,120 minitus after the drug delivering.The intra-arterial method using an artifial bilaterial super-select internal iliac artery perfunsion model defined previouysly.The intravenous method was to deliver drugs via earmarginal vena of rabbit.1mg/kg as the concentration of the drug in bladder tissure was measured by reversed-phase HPLC.Results:
The concentration of the drug in bladder tissue was significantly different between the intra-arterial and intionenous groups.Drug in the bladder tissue delivered by intra-artial method was 2.17,3.41,1.51,1.52,2.33 times as much as by intra-venous method.While drugs in blood by intra-venous method was 1.92,2.03,1.77, 1.92,1.40 times as much as by intra-arterial method.Conclusion:
HCPT is suitable for trans- arterial perfusion for the treating of bladder cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Interventional Radiology
Año:
1994
Tipo del documento:
Artículo
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