A STUDY ON NGF EXPRESSION IN LOWER RESPIRATORY TRACT AND VISCERAL AFFERENT SYSTEM OF ASTHMATIC GUINEA PIG / 解剖学报

ABSTRACT

Objective To explore the effect of nerve growth factor(NGF) in the lower respiratory tract and the visceral afferent system of asthmatic guinea pigs. Methods By means of immunohistochemistry and in situ hybridization combined with the micro-image analysis to investigate the alterations of NGF immunoreactivity and mRNA expression in asthmatic guinea pig. Results The positive NGF immunoreactivity was increased in airway epithelia,C-7-T-5 spinal ganglia and correspondent spinal dorsal horn in the asthmatic guinea pigs compared with the controls(P