The Significance of DNA Flow-cytometry in Breast Cancer / 대한암학회지
Journal of the Korean Cancer Association
; : 738-747, 1997.
Article
en Ko
| WPRIM
| ID: wpr-57162
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: To evaluate the relationship between nuclear DNA contents and prognostic factors and survival in breast cancer patients. MATERIALS AND METHODS: We determined nuclear DNA content from 91 paraffin-embedded malignant breast tumors and evaluated relationship between DNA nuclear content and well-known prognostic indicators of breast cancer and the survival of the patients by statistical analyses. RESULTS: Twenty nine (34.5%) of the 91 tumors examined were diploid, and the remainder (65.5%) contained one or more aneuploid clones. S-phase fraction (SPF) ranged from 1.4 to 68.3% (median 11.2%) and it was higher in aneuploidy tumors than in diploid tumors (p<0.05). Positive axillary lymph nodes were found in 72.7% of the patients who had a tumor with a high SPF (above the median 11.2%) and in 27.3% of those with tumor with low SPF (below median) (p<0.05). The overall survival rate was 96.1% in DNA diploid and 87.6% in DNA aneuploid tumors, showing that DNA ploidy had no prognostic significance in breast cancers. The actuarial survival rates were 96.4% and 86.3% for low and high SPF, respectively (p=0.28). The patients with high SPF showed high disease free survival rate compared to the patients with low SPF but the difference had no statistical significance. CONCLUSION: Our results indicate DNA aneuploid tumors were more prevalent in breast cancer patients with high SPF or lymph node metastasis and larger patient accumulation with longer follow-up period will be helpful to identifiy the relationship between flow- cytometrical analysis and prognosis.
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Índice:
WPRIM
Asunto principal:
Ploidias
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Pronóstico
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Mama
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Neoplasias de la Mama
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ADN
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Tasa de Supervivencia
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Estudios de Seguimiento
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Células Clonales
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Supervivencia sin Enfermedad
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Diploidia
Tipo de estudio:
Observational_studies
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Prognostic_studies
Límite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Cancer Association
Año:
1997
Tipo del documento:
Article