Therapeutical effects of salvianolic acid B on myocardial infarction in dogs / 中成药

ABSTRACT

AIM: To study the therapeutical effects of salvianolic acid B (Sal B) on myocardial infarction(MI) in dogs. METHODS: The models of myocardial infarction were produced by ligation of the left anterior descending (LAD) coronary artery in the anaesthetized dogs. The extent of myocardial ischemia was detected by epicardial-electrocardiogram and the extent of infarction was determhled by N-BT staining method. The parameter of lactate dehydrogenase was determined in the serums of dogs. RESULTS: It was indicated that the adminstration of Sal B(1、3 and 10mg/kg) by the way of intravenous injection reduced the extent of myocardial infarction (N-ST) ( P