Analyze the abnormal expression of Blys and Blys mRNA on peripheral blood mononuclear cells from patients with SLE and its clinical significance / 中华风湿病学杂志
Chinese Journal of Rheumatology
;
(12)2003.
Artículo
en Chino
| WPRIM
| ID: wpr-572403
ABSTRACT
Objective To determine the expression of membrane-bound B lymphocyte stimulator (Blys) and Blys mRNA in peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE), and investigate the relationship between Blys mRNA expression and SLE activity or lupus nephritis. Methods Measure the expression of Blys mRNA with reverse transcription-PCR (RT-PCR) in PBMCs from patients with SLE, who were separated into active group (n=26) and inactive group (n=20) according to the SLE disease activity index (SLEDAI) and 20 healthy volunteers; analyze the relationship among Blys mRNA and several clinical items; measure the expression of membrane-bound Blys with flow cytometry (FACs) in 20 patients with SLE and 16 healthy controls. Results The expression of Blys mRNA in PBMCs from patients with SLE was significantly elevated compared to healthy controls (P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Rheumatology
Año:
2003
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS