The expression and significance of MRP and LRP in carcinoma of large intestine / 重庆医科大学学报

ABSTRACT

Objective:To study the expression and clinical significance of MRP and LRP in carcinoma of large intestine.Methods:Immunohistochemistry is used to examine the MRP and LRP expression in 60 cases of large intestine carcinoma and 10 cases of normal large intestine tissues.Results:The positive expression rates of MRP and LRP in the 60 cases of large intestine carcinoma are 68.3% and 70% respectively and are all significantly higher than those in normal large intestine tissues ( P 0.05).Conclusion:MRP and LRP are both highly expressed in large intestine carcinoma and play an important role in the primary multidrug resistence(MDR) of large intestine carcinoma.