Dissolution in vitro of tetrandrine coated on nickle-titandrine alloy stent / 中成药

ABSTRACT

AIM: To prepare a nickle-titandrine alloy stent which was coated by tetrandrine from Radir stephaniae Tetrandrae and study its dissolution in vitro. METHODS: Tetradrine velease from the stent was determined by ultra-violet spectrophotometry. RESULTS: The drug releases from the stent with a equation of log(100-Rn)=- 0.0115t + 2.1730 (t=0～168 h),r= 0.9805 ,T 50 = 41.39 h,T d= 53.01 ,Kr= 0.0115 (h 1). CONCLUSION: The drug released from the stent followed first-order model kinetics. The result of tetrandrine release exhibited ideal sustanined release characteristics. The stent was suitable for clinical application.