Polymorphism in insulin receptor gene exon 17 in women with polycystic ovary syndrome / 中华妇产科杂志
Chinese Journal of Obstetrics and Gynecology
;
(12)2001.
Artículo
en Chino
| WPRIM
| ID: wpr-573593
ABSTRACT
Objective To investigate insulin receptor (INSR) genotype exon 17 frequencies in women with polycystic ovary syndrome(PCOS) and to elucidate its role in the pathogenesis of PCOS. Methods The study involved 33 women with PCOS and 28 healthy control women who were genotyped for polymorphism of INSR gene exon 17 by single strand conformation polymorphism (SSCP) analysis. Body mass index (BMI), insulin sensitive index (ISI), the expression of INSR beta subunit, and serum concentration of luteinizing hormone(LH), total testosterone between the genotypes were compared. Results (1) The T -to- C mutation was observed in the INSR gene exon 17 (1008 bp). The frequency of the C/C genotype was significantly higher in patients (39%) than in the controls (11%) (P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Obstetrics and Gynecology
Año:
2001
Tipo del documento:
Artículo
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