A Case of Secondary Cutaneous Diffuse Large B-Cell Lymphoma
Annals of Dermatology
; : 91-96, 2006.
Article
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| ID: wpr-57360
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WPRO
ABSTRACT
We report here on a case of secondary cutaneous diffuse large B-cell lymphoma (DLBCL) that occurred in a 67-year-old man who had a 2-month history of nodular growing masses on the left cheek, plus palpable lymph nodes on the left cervical area. The histopathological findings showed a diffuse infiltration of large atypical lymphocytes with nuclear atypia throughout the entire dermis. These showed positive CD20, bcl-2 and the post-germinal center marker, MUM-1. According to the WHO (World Health Organization) classification, this lymphoma is considered to be diffuse large B-cell lymphoma of the post-germinal center (GC) B-cell type with a secondary cutaneous manifestation. We treated the patient with systemic chemotherapy (CHOP) and anti-CD20 monoclonal antibodies. During the course of treatment, new skin lesions developed on his neck, so we changed the regimen to cytosin- arabinoside and cisplatin. But he died of pneumonia after the third cycle.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Neumonía
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Piel
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Organización Mundial de la Salud
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Linfocitos B
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Linfocitos
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Mejilla
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Linfoma de Células B
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Cisplatino
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Clasificación
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Dermis
Límite:
Aged
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Humans
Idioma:
En
Revista:
Annals of Dermatology
Año:
2006
Tipo del documento:
Article