Pharmacokinetics of ligustilide in the volatile oil from Angelica Sinensis(Oliv.) Diels in rabbit / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Artículo
en Chino
| WPRIM
| ID: wpr-574422
ABSTRACT
AIM:
To study the pharmacokinetics of ligustilide in the volatile oil from Angelica Sinensis(Oliv.) Diels in the rabbit.METHODS:
HPLC method for ligustilide determination in the blood was developed.The HPLC system consisted of C_(18) column using MeOH-H_2O(65∶35,v/v) as mobile phase at a flow rate of 1.0 mL/min and UV detection at 236 nm.RESULTS:
Linear calibration curves were obtained over the concentration range of 0.40 ?g?mL~(-1)~10.00 ?g?mL~(-1) for ligustilide.The minimum limit detection was 0.40 ?g?mL~(-1).The recovery of ligusitilide in blood was 90.90% with RSD 2.74%.CONCLUSION:
After oral administration of volatile oil,intracorporal process of ligustilide in rabbit accords with 2-compartment model with 1 st order absorption,(2.6638) h and 108.88 h are obtained as t_(1/2?) and t_(1/2?) respectively.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Traditional Patent Medicine
Año:
1992
Tipo del documento:
Artículo
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