Clinical Trial of Paclitaxel Combined with Radiotherapy for the old Patients with Advanced Non - Small Cell Lung Cancer / 重庆医科大学学报

ABSTRACT

Objective; To evaluated the effects and toxicity of Taxol + radiotherapy( RT) regimen and Taxol + CBP regimen for the old patients of advanced non - small cell lung cancer. Methods: 51 old patients of advanced non - small cell lung cancer were randomized into two groups. There are 25 cases in Taxol + CBP group, administrated with Taxol 135mg/m2 ,d1, CBP AUC5 ,d2. The regimen was repeated every 21 days. There are 26 cases in Taxol + RT group, administrated with Taxol 135mg/m2 ,dl ,d30, radiotherapy started on second day, DT65 -70Gy. Results; The total effective rate and clinical benefit response(CBR) in Taxol + RT group were much higher than Taxol + CBP group. 1 - year,2 - year survival rate of Taxol + CBP group were 49. 8% ,21. 7% .while 52. 3% ,23.2% in Taxol + RT group respectively. There was significant difference between two groups in median survival time (MST) (P