Protective effects of Jidesheng Sheyao tablet on endotoxin-induced acute lung injury in rats / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
;
(12)2006.
Artículo
en Chino
| WPRIM
| ID: wpr-574857
ABSTRACT
Objective To investigate the protective role of Jidesheng Sheyao tablet in lipopolysaccharide (LPS)-induced acute lung injury(ALI) in rats. Methods Fifty male SD rats were randomly divided into 6 groupsnormal control group,dexamethasone positive group,LPS model group, Sheyao groups of low, middle and high dosages successively.All rats, except normal control group, were administrated with LPS by intravenous injection to induce acute lung injury. The rats in positive group and three different dosage groups were treated by dexamethasone(3 mg?kg -1, iv), low dosage(0.8 g?kg -1), middle dosage(1.6 g?kg -1) and high dosage(3.2 g?kg -1) of Jidesheng Sheyao tablet(oral) respectively before LPS-induced ALI. Each rat in normal control group received injection of 1ml normal saline. The animals were killed after injection of LPS for 2 hours, and then the lung index was calculated, the histopathology of the lung injury was observed by light microscope, the expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) proteins in the lung tissues and their activity in the bronchoalveolar lavage fluid (BALF) and the lung homogenates were detected by immunohistochemistry and zymography separately. Results Compared with model group, the lung indexes were significantly decreased in the drug groups(P
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Emergency Medicine
Año:
2006
Tipo del documento:
Artículo
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