Pathological regression at the focus in normal New Zealand Rabbits' brain tissue after high intensity focused ultrasound ablation / 重庆医科大学学报

ABSTRACT

Objective: To determine if HIFU is secure and effective for the treatment of intracranial neoplasm by observing pathological regression at the focus in normal New Zealand Rabbits' brain tissue after ablation.Methods: We selected suitable doses of exposure to ab-late 12 rabbits' brain tissue,and sacrificed them successively at 1,3,7,14,28 and 60 days(d) after sonication,observing target lesions grossly and microscopically to identify the biological characteristic and pathologic changes.The ultra-structural changes were also observed immediately after sonication.Results: We took the 5s and 10s for each exposure time in the studies.Different ranges of lesions were pro-duced after different exposure time,especially on 28d,although grossly and microscopically the lesion were almost the same in early period.Finally the 10s sonicated area regressed to scar of glia,but no apparent lesion was found in the 5s area.Ultra-structural examination showed the integrity of cell and vascular structure were destructed in 10s area,but remained intact in 5s area.Conclusion: HIFU could ab-late deep localized brain tissue with little effect on the superficial brain tissue.The restoring mode of sonicated lesion is correlated with ex-posed doses,and it is reversible when using suitable dose of exposure.In conclusion,it is secure and effective to use suitable dose of HIFU in the treatment of intracranial neoplasm and some experimental data are provided for future clinical investigation.