Establishment of adriamycin-induced dilated cardiomyopathy model in rabbits / 重庆医科大学学报

ABSTRACT

Objective:To explore the feasibility of adriamycin-induced dilated cardiomyopathy model in rabbits.Methods:26 rabbits were given 1mg.kg-1 body wt.of adriamycin intravenously twice a week for 8 weeks,then received echocardiography and histoligical examination after 3 weeks of final injection.Results: 17 rabbits survived.Compared to the baseline station,the value for the Left ventricular diastolic dimension(LVEDD) and the Left ventricular systolic dimension(LVESD) increased significantly,while the value for the Left ventricular ejection fraction(LVEF)and the Left ventricular short fraction(LVFS) decreased significantly after treated with adriamycin(P