Expressions of cFLIP and FADD in cervical carcinoma and their significances / 重庆医科大学学报

ABSTRACT

Objective:To investigate the expressions of cFLIP and FADD in cervical carcinoma and explore their associations with the carcinogenesis and development of cervical carcinoma,and to evaluate their clinical significances.Methods:The expressions of cFLIP and FADD proteins were detected in cervical tissue samples including 64 cervical carcinoma tissues,15CIN,12 chronic cervicitis tissues and 10 normal cervix tissues by immunohistochemistry(SP).And PCNA-LI in 64 cervical carcinoma samples was determined.Results:cFLIP and FADD expressions were significantly different among cervical carcinoma,CIN,chronic cervicitis tissue and normal cervix.The high expression of cFLIP and low expression of FADD were simultaneously found in cervical carcinoma.Statistical analysis showed that there was a positive correlation between the level of cFLIP expression and PCNA-LI(r1=0.7738,P