Effect of Chronic Aplastic Anemia Treated with Promoting Kidney and Tonifing Bone Method on the Expression of Hematopoiesis Regulation Factors IL-3,SCF,IFN-? and TNF-? mRNA / 中国中医药信息杂志

ABSTRACT

Objective To observe the effect of chronic aplastic anemia patients treated with promoting kidney and tonifing bone herbs on the expression of hematopoiesis regulation factors,and discuss the mechanism of kidney-promoting herbs. Methods 120 cases of chronic aplastic anemia were randomly divided into two groups,90 cases treated with promote kidney and tonify bone method,and 30 cases treated with western medicine. Besides these,10 cases of volunteers’ bone marrow were collected as normal control. Hematopoiesis regulation factors such as SCF,IL-3,TNF-? and IFN-? mRNA semi-quantitative expression were observed by RT-PCR. Results The expression level of SCF and IL-3 mRNA in two groups was lower obviously than normal control(P