Curative effect of Lumbago Suppository on prolaps of intervertebral disc in rat / 中成药

ABSTRACT

AIM: According to the functions of Lumbago Suppositiory (Radix Aconiti, Ramulus Cinnamoni, Moschus, etc) (LS), we observed the connection among anti-inflammatory, analgesia and promoting blood circulation and removing blood stasis. METHODS: Rat chemical radiculoneuritis model was set up to observe influence of LS on inflammation, pain threshold, gait and PLA_2 in serum, content of adrencorticoids and adrenalin. Cold accumulation type of blood stasis symptom model was built up to observe the influence of LS on blood rheological property, effect of LS on mouse's micro-circulation in ears was also observed. RESULTS: Lumbago Suppository inhibited inflammation of rat radiculoneuritis model obviously and had recovery of functions for gait and pain threshold. And it also could reduce the content of PLA_2 in serum and raise the level of adrenocorticoids and adrenalin. It also obviously changed "blood stasis symptom”, rat blood rheological property and auricle micro-circulation of mouse. CONCLUSION: Lumbago Suppository's functions of anti-inflammatory and analgesia have strong relation ships with promoting blood circulation and removing blood stasis.