Decrease in Plasma Adiponectin Concentrations in Patients with Vasospastic Angina
Korean Circulation Journal
; : 255-260, 2006.
Article
en En
| WPRIM
| ID: wpr-57661
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WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. SUBJECTS AND METHODS: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. RESULTS: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6+/-5.4 vs. 5.2+/-4.0 vs. 9.0+/-6.2 microgram/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. CONCLUSION: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Plasma
/
Humo
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Dolor en el Pecho
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Enfermedad de la Arteria Coronaria
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Resistencia a la Insulina
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Fumar
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Acetilcolina
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Análisis Multivariante
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Angiografía Coronaria
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Vasoespasmo Coronario
Límite:
Female
/
Humans
Idioma:
En
Revista:
Korean Circulation Journal
Año:
2006
Tipo del documento:
Article