Bioavailability Comparison Between Andrographolide Oral Microemulsion and Andrographolide Pill in Rabbits / 中药新药与临床药理
Traditional Chinese Drug Research & Clinical Pharmacology
;
(6)1993.
Artículo
en Chino
| WPRIM
| ID: wpr-576740
ABSTRACT
Objective To compare the difference in bioavailability of microemulsion and pill by detecting the concentration of andrographolide in rabbit plasma.Methods RP-HPLC was used to detect the concentration of andrographolide in rabbits plasma at different time,and software 3p87 was used to analyze the pharmacokinetics parameter.Results The pharmacokinetics parameters of andrographolide oral microemulsion and andrographolide pill were as followsAUC0-7=1 406.72 ? g? mL-1? min,Tpeak=27.08 min,Cmax=5.37 ? g/mL for microemulsion;AUC0-7=877.37 ? g? mL-1? min,Tpeak=61.04 min,Cmax=3.06 ? g/mL for the pill.Conclusion Oral microemulsion of andrographolide has a shorter peak time and higher biological availability than the pill.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Traditional Chinese Drug Research & Clinical Pharmacology
Año:
1993
Tipo del documento:
Artículo
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