Effect of bone marrow stem cell mobilization in resolusion of deep vein thrombosis / 重庆医科大学学报

ABSTRACT

Objective:To explore the effect of bone marrow stem cell mobilization in resolution of deep vein thrombosis.Methods:The SD adult rats were randomly divided into normal,sham,surgical and mobilization group(with subcutaneous injection of rhG-CSF).The peripheral blood mononuclear cell count,pathological change and thrombus organization rate in different time were examined.Results:The peripheral blood mononuclear cell count in mobilization group was significantly elevated,and there was no significant change in other groups.Compared with surgical group,there were more inflammatory cells in thrombus of mobilization group at 7th postoperative day,and the organization area of thrombus was wider and the organization rate was significantly different in mobilization group at 14th postoperative day(P