Effect of Xinjihuoliyin on Myocardium Injury Induced by Adriamycin in Rats / 中国中医药信息杂志
Chinese Journal of Information on Traditional Chinese Medicine
;
(12)2006.
Artículo
en Chino
| WPRIM
| ID: wpr-577007
ABSTRACT
Objective To observe the protective and antioxidative effect of Xinjihuoliyin on the myocardium injury induced by adriamycin (ADM) in rats. Methods 80 SD rats were randomly divided into four groupsnormal group, control group, Xinjihuoliyin group and positive control group (Huangqishengmaiyin group). In control group, Xinjihuoliyin group and Huangqishengmaiyin group, ADM was intraperitonial injected at a dose of 2.5 mg/kg, three times every week, for 4 weeks, while normal saline was intraperitonial injected at a dose of 3 mL/kg in normal group. In Xinjihuoliyin group, Xinjihuoliyin was intragastric administrated once a day at a dose of 10 g/kg. In Huangqishengmaiyin group, Huangqishengmaiyin was intragastric administrated once a day at a dose of 7 mL/kg and distilled water was given to other two groups. The activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) of serum and myocardium were assayed. The myocardial pathomorphism was detected at the same time. Results Compared with the control group, MDA of serum and myocardium was lower, and SOD of serum and myocardium was higher in Xinjihuoliyin and Huangqishengmaiyin group. The scale of myocardial pathological damage in Xinjihuoliyin and Huangqishengmaiyin group was improved. Conclusion Xinjihuoliyin has protective effect and antioxidative effect on the myocardium injury induced by adriamycin in rats.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Information on Traditional Chinese Medicine
Año:
2006
Tipo del documento:
Artículo
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