Influences on Pharmacokinetics of Hydrochloric Berberine in Rats Administrated Gangtai with 3 Routes / 中国中医药信息杂志
Article
en Zh
| WPRIM
| ID: wpr-577107
Biblioteca responsable:
WPRO
ABSTRACT
Objective To observe and compare the pharmacokinetics of hydrochloric berberine in rats administrated Gangtai by 3 routes.Method Rats were taken orally or administrated Gangtai by abdomen skin or rectal,and their serum concentrations of hydrochloric berberine at different time(0~30 h)were determined with HPLC method.Results The main pharmacokinetics parameters of hydrochloric berberine by abdomen skin,rectal and oral administration:Cmax was 127.4,269.4,127.9 g/L respectively,Tmax was 1,0.5,0.5 h respectively,AUC0-30 h was 161 1.44,105 5.61,765.88 g/(L?h)respectively.Conclusion The pharmacokinetics parameters of Gangtai in rats provided academic evidence for clinical application of Gangtai.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Information on Traditional Chinese Medicine
Año:
2006
Tipo del documento:
Article