Characteristic pattern of neuron firings at hippocampus CA1 for fast-aging mouse / 国际生物医学工程杂志
International Journal of Biomedical Engineering
;
(6): 24-26,30, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-577857
ABSTRACT
Objective To investigate the effect of fast-aging on the excitability of hippocampus CA1 neurons in mouse and the possible interaction between fast-aging and hippocampus. Methods Using brain slice and extracellular recording technique to record the firing of hippocampus CA1 neurons in fast-aging(SA M-P/8) and normal control mice, after preprocessing, neural firing train were obtained. Using neural firing rate and inter-spike-inter to investigate interaction between fast-aging and hippocampal neural firing. Results The neural firing rate of hippocampus CA1 neurons in fast-aging mice is (1.052±0.364) Hz(n=14), while the neural firing ratein normal control mice is (4.416±1.306) Hz(n=22). In fast-aging mice, 80.5% inter spike intervel(ISI) is longerthan 1sec, but in normal control mice, 95.6% ISI is shorter than 0.5sec. Conclusion The decreased firing rate of hippocampus CA1 and longer ISI observed in the fast-aging mice indicates that fast-aging significantly inhibit hippocampal CA1 neurons excitability.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Biomedical Engineering
Año:
2010
Tipo del documento:
Artículo
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