Therapeutic Effect of Guanxin Prescription No.1 for Coronary Heart Disease and Its Influence on Homocysteine / 广州中医药大学学报

ABSTRACT

Objective To observe the therapeutic effect of Guanxin Prescription No.1 (GP1)for coronary heart disease (CHD)and its influence on homocysteine (Hcy).Methods Sixty CHD patients were equally randomized into two groups.Both of the two groups received routine western medicine,and the treatment group additionally received GP1 (mainly composed of Radix Codonopsis,Radix Ophiopogonis,Fructus Schisandrae Chinensis,Rhizoma Polygonati Odorati,Rhizoma Chuanxiong,Rhizoma Anemarrhenae,Radix Salviae Miltiorrhizae,Radix Notoginseng,Radix Curcumae,etc).Four weeks constituted one treatment course.The total therapeutic effect and the effect on angina pectoris (AP)and electrocardiogram (ECG)were evaluated after treatment.Meanwhile,the changes of blood lipid levels,serum Hcy and internal-middle thickness (IMT)of carotid artery were observed.Results The total therapeutic effect and the effect on AP and ECG in the treatment group were superior to those in the control group (P0.05 compared with those before treatment).The decrease of serum Hcy level was obvious in the treatment group than that in the control group (P