In vitro evaluation of indirubin self-emulsifying drug delivery system / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
en Zh
| WPRIM
| ID: wpr-578380
Biblioteca responsable:
WPRO
ABSTRACT
AIM: To prepare indirubin self-emulsifying drug delivery system(SEDDS) and evaluate it in vitro. METHODS: The criteria of SEDDS formation was studied and indirubin SEDDS preparation optimized with triangle phase diagram.In order to investigate self-emulsifying ability,the time of self-emulsifying,particle size of emulsion and the dissolution of indirubin in vitro were determined. RESULTS: The best formulation of SEDDS was made up of labrasol-peceol-transcutol P(85∶10∶5),which served as oil phase,emulsifier and assistant emulsifier,respectively.The selected formulation could completely emulsify in 5 min and the particle size was about 100 nm.As compared with indirubin suspension,SEDDS could improve drug dissolution significantly. CONCLUSION: SEDDS can give rise to the dissolution increase of slightly soluble drug in water in vitro.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Traditional Patent Medicine
Año:
1992
Tipo del documento:
Article