Improvement in the solubility of mangiferin by HP-?-CD inclusion / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
en Zh
| WPRIM
| ID: wpr-578535
Biblioteca responsable:
WPRO
ABSTRACT
AIM:To study the optimum condition of hydroxypropyl-?-cyclodextrin inclusion for mangiferin in order to improve the solubility of mangiferin. METHODS: By comparing the condition of inclusion of mangiferin in hydroxypropyl-?-cyclodextrin obtained,including its drying method,inclusion compound stood the test of infrared spectrophotometry,UV spectrophotometry,differential scanning calorimetry analysis,phase solubility diagran and solubility determination. RESULTS: The paddling process and freeze drying could put in HP-?CD inclusion compound use the ratio of host/guest molecules was 1∶1,the solubility of mangiferin of included complex was 35.99 mg/mL,about 300 times as large as uninclused mangiferin(0.111 mg/mL). CONCLUSION: Hydroxypropyl-?-cyclodextrin inclused mangiferin compound could be prepared by paddling process and freeze drying.Its solubility of the compound improves significantly and it is stable.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Traditional Patent Medicine
Año:
1992
Tipo del documento:
Article