The expression of cancer suppressor gene maspin in the HCC and its correlation with AFP and its clinical significance / 重庆医科大学学报

ABSTRACT

Objective:To study the protein expression of maspin in the HCC and its correlation with AFP,and to discuss its clincal significance.Methods:the protein expressions of maspin and AFP in the normal liver tissue(NT),paratumor tissue(PT)and liver tumor tissue(TT)were detected with immunohistoch-emistry and their area densities were measured.A total of30 patients with HCC and 30 patients without HCC in our Department of Hepatobiliary Surgery were as samples from March,2004 to December,2005.Results:(1)The area densities(AD)of maspin protein in the NT,PT and TT were 20 712.48?1 826.28,7 347.40?441.16,85.68?19.81 respectively,but the area densities of AFP protein were 66.00?10.70,7 005.04?335.69,13 094.00?516.32 respectively;the comparion of two was P