A study on the enhancement of therapeutic efficacy of HIFU by magnetic nano-particles / 重庆医科大学学报

ABSTRACT

Objective:To investigate the effects of magnetic nano-particles on the therapeutics efficacy of high intensity focused ultrasound(HIFU).Methods:The magnetic nano-particles with diameter of 80～90 nm and 200～300 nm were distributed into the egg white phantom respectively.At the same HIFU exposure dose,the length and width of the maximum cross section of the lesions were measured.Results:The results showed that the magnetic nano-particles with diameter of 200～300 nm can enhance the therapeutic efficacy of HIFU,and the areas of lesions were about 2 times larger than those of control group(P0.01).Conclusion:The magnetic nano-particles with diameter of 200～300 nm can change the acoustics environment of egg white phantom and enhance the therapeutic efficacy of HIFU.