Effects of FuYuan capsule on the expression of TIMP-1 and TGF-?1 in liver of hepatic fibrosis in Rats / 重庆医科大学学报

ABSTRACT

Objective:To study the effects of FuYuan capsule on rat liver fibrosis induced by pig serum.Methods:The rats were randomly divided into six groups,including the normal group,the model group,the low,middle and high dose FuYuan capsule group,and the positive control group(compound Biejiaruangan-chip solution).The rat models of immune liver fibrosis were induced with pig serum.Alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in serum were detected with autoumatic biochemical analyzer.Hyaluronan(HA),laminin(LN).IV collagen(IV-C)and the typeⅢcollagen(PCⅢ)in serum were quantified by radiative-immune technology.The expression of TIMP-1(tissue inhibitor of metalloproteinases-1)and TGF-?1(transforming growth factor?-1)in the liver were observed by immunohistochemical assay.Results:ALT,AST,HA,LN,IV-C and PCⅢin the model group were significantly higher than those in the other group(sP