Three Cases of Flagellate Pigmentation from Intravenous Bleomycin / 대한피부과학회지
Korean Journal of Dermatology
;
: 317-321, 1997.
Artículo
en Coreano
| WPRIM
| ID: wpr-57983
ABSTRACT
Bleomycin is an antitumoral antibiotic derived from Streptomyces verticillus in 1965. The drug has been used with a varying success in the treatment of squamous cell carcinomas and malignant lymphomas. The cutaneous toxicities of bleomycin include hyperpigmentation, sclerosis, gangrene, nail changes and erythema. Linear streaks appear to be a characteristic eruption induced by bleomycin. We report three cases of flagellate pigmentation from intravenous bleomycin. Three patients were suffering from uterine cervical carcinomas and were treated with chemotherapy with a VBP (vincristine, bleomycin, cisplatire) regimen. During or after their courses of chemotherapy, dark brownish skin lesions developed on the body surface of these patients. A Light microscopic study of each specimen showed increased pigmentation of the basal layer and an electron microscopic study showed a slightly increased number of melanosomes in keratinocytes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esclerosis
/
Piel
/
Streptomyces
/
Bleomicina
/
Pigmentación
/
Carcinoma de Células Escamosas
/
Queratinocitos
/
Hiperpigmentación
/
Melanosomas
/
Quimioterapia
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Año:
1997
Tipo del documento:
Artículo
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