A new second messenger system:the nuclear phosphoinositide 3-kinase/Akt pathway / 基础医学与临床

ABSTRACT

Lipid second messengers,particularly phosphoinositides,play a pivotal role in several cell signaling networks.Specific inositol lipids such as PtdIns(3,4)P_(2) and PtdIns(3,4,5)P_(3) which are generated by phosphoinositide 3-kinases(PI3Ks) are specific activators to the serine/threonine protein kinase Akt that have been implicated in a plethora of cell functions.Studies show that Akt stimulates cell proliferation and suppresses apoptosis,and is implicated in cancer progression.Many evidences have highlighted the presence of an autonomous nuclear inositol lipid metabolism,and suggest that lipid molecules are important components of signaling pathways in the nucleus.