Anti-inflammatory Action and Pharmacodynamics of Liushen Cataplasm / 中药新药与临床药理
Article
en Zh
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| ID: wpr-580516
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WPRO
ABSTRACT
Objective To sutdy the anti-inflammatory action and pharmacodynamics of Liushen Cataplasm (LC). Methods The anti-inflammatory action of LC was observed on mice models of xylene-induced ear swelling and on the rat models of carrageenan-induced pedal swelling. With the decrease of pedal swelling as the parameter,the pharmacodynamics of LC was studied. The apparent parameters of pharmacodynamics were estimated based on the time-effect curve. Results LC showed a potent anti-inflammatory effect. The effect-time curve can be described by the one-compartment model. The main pharmacodynamic parameters were as follows:t1/2(Ka)=2.11727h,t1/2(Ke)=3.13464h,AUC=3.33131 mg?kg?h-1,respectively. Conclusion Liushen Cataplasm shows a potent anti-inflammatory effect. The effect-time curve can be described by the one-compartment model.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Traditional Chinese Drug Research & Clinical Pharmacology
Año:
1993
Tipo del documento:
Article