Lineage Switch at Relapse of Childhood Acute Leukemia: A Report of Four Cases
Journal of Korean Medical Science
;
: 829-831, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-58115
ABSTRACT
Lineage switch in acute leukemia is an uncommon event at relapse, and therefore rarely reported in the literature. Here, we have described the clinical laboratory features of four cases in which the cell lineage switched from acute lymphoblastic leukemia (ALL) to acute myeloid leukemia (AML). One patient was initially diagnosed with B-ALL, switched to T-ALL at the first relapse, and eventually, AML at the second relapse. A lineage switch represented either relapse of the original clone with heterogeneity at the morphologic level or emergence of a new leukemic clone. Further sequential phenotypic and cytogenetic studies may yield valuable insights into the mechanisms of leukemic recurrence, with possible implications for treatment selection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Recurrencia
/
Trasplante Homólogo
/
Médula Ósea
/
Leucemia Mieloide Aguda
/
Enfermedad Aguda
/
Inmunofenotipificación
/
Aberraciones Cromosómicas
/
Terapia Recuperativa
/
Trasplante de Células Madre Hematopoyéticas
/
Linaje de la Célula
Límite:
Niño
/
Femenino
/
Humanos
/
Lactante
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2011
Tipo del documento:
Artículo
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