Expression and significance of Ki-67,MMP-2 and MMP-7 in CIN and cervical cancer / 重庆医科大学学报

ABSTRACT

Objective:To investigate the Ki-67,MMP-7,MMP-2 expression in cervical intraepithelial neoplasm(CIN)and cervical cancer,with the aim of evaluating their association with the development,aggressiveness and lymph node metastasis.Methods:The immunohistochemical S-P method and image analysis were used to detect Ki-67,MMP-7,MMP-2 expression in 50 cases with cervical cancer,23 cases with CIN and 20 cases of normal control.Results:Ki-67,MMP-7,MMP-2 were mainly expressed in the membrane and /or cytoplasm in tumor cells.The positive rate of Ki-67,MMP-7and MMP-2 were 72.00%,78.00%,76.00%in carcinoma,47.83%, 60.87%,56.52%in CIN lesions,10,0,0 in normal cervical tissues respectively.Expression rate in ICC was obviously higher than that in control group(P0.05).High grade diseases and those with lymph node involved presented with higher ki-67 expression than low grade diseases and those without lymph node metastasis(P