Evaluation of point plaster therapy with ginger powder in preventing nausea and vomiting occurred after platinum-based interventional chemotherapy in patients with primary or metastatic liver cancer / 介入放射学杂志

ABSTRACT

Objective To evaluate the point plaster therapy with ginger powder combined with ondansetron hydrochloride in preventing nausea and vomiting usually occurred after platinum-based interventional chemotherapy in patients with primary or metastatic liver cancer,and to compared its effectiveness with that by using ondansetron hydrochloride only. Method Sixty-two patients with primary or metastatic liver cancer,who were scheduled to receive platinum-based interventional chemotherapy,were randomly and equally divided into two groups with 31 cases in each group. The patients in the study group (n = 31) were given point plaster therapy,i.e. externally applying ginger powder (20 g) to the point of Shenque,for four days together with arterial infusion of ondansetron hydrochloride (8 mg) during interventional procedure,while the patients in the control group (n = 31) were given point plaster therapy with placebo (potato powder) together with arterial infusion of ondansetron hydrochloride (8 mg) during interventional procedure. The questionnaire of INVR (index form for evaluating nausea and vomiting) was used to assess the effectiveness,and the results were compared between two groups. Results The incidence of nausea and vomiting in study group was significantly lower than that in control group at all observed points of time during the period of 0 -72 hours after the treatment (P 0.05). After the treatment the scores of nausea,vomiting and retching in the study group were 0.45,0.25 and 0.19 respectively,while these in the control group were 2.77,0.87 and 0.97 respectively,the differences between two groups were statistically significant (P