TOXICITY AND TISSUE SCHIZONTOCIDAL ACTIVITY OF PRIMAQUINE COMBINED WITH PYRONARIDINE IN LABORATORY ANIMALS / 中国寄生虫学与寄生虫病杂志
Chinese Journal of Parasitology and Parasitic Diseases
;
(6)1987.
Artículo
en Chino
| WPRIM
| ID: wpr-581400
ABSTRACT
Groups of mice were administered intragastrically either with primaquine alone or in combination with pyronaridine. The number of mice died in groups treated by pyronaridine 293-507 mg/kg combined with primaquine 50 mg/kg were not more than those in group by primaquine alone, but significantly less than those in groups by combination of chloroquine 102-253 mg/kg and primaquine. The tests of primary tissue schizontocidal activity in rhesus monkeys inoculated, with Pladmodium cynomolgi sporozoitcs showed that all monkeys were cured either by treatment of ig primaquine alone, 3 mg/kg/d ? 3, or by a single im dose of pyronaridine 10 mg/kg combined with primaquine starting on the day of infection. No influence of pyronaridine on primaquine was observed in P. yoelii sporozoites-infected mice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Parasitology and Parasitic Diseases
Año:
1987
Tipo del documento:
Artículo
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